Adjunctive therapy to diet in patients w/ primary (heterozygous familial & non-familial) hypercholesterolaemia in whom a statin is inappropriate or not tolerated; in patients w/ homozygous familial sitosterolaemia. In combination w/ a statin as adjunct to diet in patients w/ primary (heterozygous familial & non-familial) hypercholesterolaemia who are not appropriately controlled w/ a statin alone; in patients w/ HoFH.
Hypersensitivity. Combination w/ a statin: Pregnancy & lactation; in patients w/ active liver disease or unexplained persistent elevations in serum transaminases.
Take at least 2 hr before or 4 hr after administration of a bile acid sequestrant. Perform liver function tests at treatment initiation when co-administering w/ a statin. Risk of myopathy. Should not be taken by patients w/ rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May impair ability to drive or operate machinery. Not recommended in patients w/ moderate or severe hepatic impairment. Pregnancy. Should not be used during lactation. Not recommended in childn <10 yr.
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